Covid-19 +

More
3 months 5 days ago #44327 by Isamorph
Covid-19 + was created by Isamorph
Nice Covid-19 info state by state. And more.



www.us-covid-tracker.com/?per100k=0&log=0&field=newDeaths&state=California&consistentY=1



The following user(s) said Thank You: Soteria 2.0, KBOrtega, dst11, y4vix

Please Log in or Create an account to join the conversation.

More
3 months 4 days ago #44333 by SuccessOne
Replied by SuccessOne on topic Covid-19 +
The following user(s) said Thank You: Soteria 2.0

Please Log in or Create an account to join the conversation.

More
3 months 3 days ago #44360 by KentE
Replied by KentE on topic Covid-19 +

y4vix wrote:
And on another front:
Hydroxychloroquine rated 'most effective therapy' by doctors for coronavirus: Global survey
www.washingtontimes.com/news/2020/apr/2/hydroxychloroquine-rated-most-effective-therapy-do/


To keep that part in context, ranking was based on anecdotal surveys of doctors, without any tests. The other popular options were analgesics (pain relievers), a particular antibiotic (kind of a shotgun approach, aimed more at 'what if it's not coronovirus' since it's an antibacterial & not anti-viral), and 'nothing' (addressing & relieving the symptoms, rather than directly fighting the virus.)
In other words, hydroxychloroquine got votes primarily out of hope, and because there were no other real choices.

I hope it works, at least to lessen the severity and duration.
The following user(s) said Thank You: Isamorph, Soteria 2.0, dst11

Please Log in or Create an account to join the conversation.

More
3 months 3 days ago #44364 by Isamorph
Replied by Isamorph on topic Covid-19 +
Re: vaccine--- Even if testing protocols are relaxed, I suspect at least a year away from implementation, assuming it works, but better late than never--“Testing in patients would typically require at least a year and probably longer,” Falo said. “This particular situation is different from anything we’ve ever seen, so we don’t know how long the clinical development process will take. Recently announced revisions to the normal processes suggest we may be able to advance this faster.”

www.upmc.com/media/news/040220-falo-gambotto-sars-cov2-vaccine

The following user(s) said Thank You: Soteria 2.0, dst11, y4vix

Please Log in or Create an account to join the conversation.

More
3 months 3 days ago #44370 by st3fx
Replied by st3fx on topic Covid-19 +
The increasing use of hydroxychloroquine (sometimes given in combination with azithromycin) is because it is an FDA-approved drug. In theory, Remdesivir as a treatment option makes more sense though.

I wish experimental treatment options could be made available prior to onset of ARDS, especially for immunocompromised and/or elderly populations. Same goes for the vaccines undergoing clinical trials. I know some elderly folks with underlying health conditions willing to roll the dice on untested vaccines.

So far, one issue I see with outcomes of "compassionate use" of Remdesivir is it is often given so late in the progression of the disease. With seasonal influenza, for example, Tamiflu should be administered within 48 hours of symptoms onset in order to be effective.
The following user(s) said Thank You: jamielih, als, Isamorph, Soteria 2.0

Please Log in or Create an account to join the conversation.

  • PEW
  • PEW's Avatar
  • Telepathy
  • Telepathy
More
3 months 3 days ago #44384 by PEW
The following user(s) said Thank You: uhthisb, dst11

Please Log in or Create an account to join the conversation.

More
3 months 3 days ago #44390 by Soteria 2.0
Replied by Soteria 2.0 on topic Covid-19 +
A small trial finds that hydroxychloroquine is not effective for treating coronavirus
20, 8:40 AM EDT


Like the Marseille study, the Molina trial was also a small pilot study. Molina and colleagues used the same dosing regimen as Gautret. In contrast, however, to the Gautret study, eight of the 11 patients had underlying health conditions, and 10 of 11 had fevers and were quite ill at the time the dosing began.

These Paris researchers found that after five to six days of treatment with hydroxychloroquine (600 mg per day for 10 days) and azithromycin (500 mg on day 1 and 250 mg on days 2 to 5), eight of the 10 patients still tested positive for COVID-19. Of these 10 patients, one patient died, two were transferred to the ICU and another had to be removed from the treatment due to serious complications.




Study of a total of eleven patients.
Eight of which had underlying health conditions.
Ten of the eleven had fevers and we're quite ill at the time the dosing began.
The following user(s) said Thank You: dst11, y4vix

Please Log in or Create an account to join the conversation.

More
3 months 2 days ago #44396 by Soteria 2.0
Replied by Soteria 2.0 on topic Covid-19 +
Long Island doctor tries new twist on hydroxychloroquine for elderly COVID-19 patients
By Lorena Mongelli

April 4, 2020 | 1:30am


A New York doctor hopes to help his elderly COVID-19 patients with a treatment plan inspired by the success tentatively being reported with hydroxychloroquine -- and which he says shows promising results.
A New York doctor hopes to help his elderly COVID-19 patients with a treatment plan inspired by the success tentatively being reported with hydroxychloroquine -- and which he says shows promising results.


A New York doctor hopes to help his elderly COVID-19 patients with a treatment plan inspired by the success tentatively being reported with hydroxychloroquine — and which he says shows promising results.

Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, said 81 percent of infected covid patients he treated at three Long Island nursing homes recovered from the contagion.

“In this crisis, I realized I had to do something,” Alam said. ”I realized if this was my dad, what would I do? And I would do anything I could to help.”

Alam said he decided he could not apply the touted combination of the antimalarial hydroxychloroquine and antibiotic azithromycin because the side effects could be potentially fatal for his high-risk patients, many of whom had underlying heart issues.


“I knew I could not jeopardize these patients,” Alam said.

“We know from the FDA that azithromycin can cause fatal arrhythmia and abnormal heart failure that can lead to death,” Alam said.

His patients were under long-term acute care and had comorbidities such as hypertension, coronary artery disease, chronic obstructive pulmonary disease or congestive heart failure.

The FDA has warnings that azithromycin “can cause abnormal changes in the electrical activity of the heart that may lead to a potentially fatal irregular heart rhythm.”

So instead, Alam replaced azithromycin with another decades-old antibiotic that doesn’t pose any known risks to the heart.

“Doxycycline is an anti-inflammatory with properties similar to azithromycin but without the safety concerns and without cardiac toxicity,” he said.

“So I decided why not choose that?” added Alam, a board-certified internist, who shared the results of an observational report consisting of 47 patients he treated.


”With the [limited]resources we have at the nursing home, we took a deep breath and realized we need to do something,” Alam said.

Alam is not the only one to begin using doxycycline in the fight against COVID-19.

Henry Ford Health System has started using combinations of the three drugs because of apparently fewer side effects, published reports state.

Alam began treating his patients, 45 of whom had tested positive for the coronavirus after they developed a high fever, shortness of breath and cough.

He received permission from their families before starting them on the medications, which have not yet undergone randomized controlled trials.

“The majority had clinical improvement,” said Alam. “We had very good outcomes.”

Alam said that 38 of 47 patients treated returned to their baseline and their symptoms resolved. Seven of the patients were transferred to a hospital and two died.


There was no control group in the study so Alam acknowledged more studies are needed to evaluate his protocol’s effectiveness.



Alam noted that an 87-year-old woman with hypertension and coronary issues beat the virus. “Her daughter was so thankful that I didn’t need to transfer her to a hospital.”

“At the end of the day we feel like we sent fewer patients to the hospitals, we saved ICU beds and we saved some of the ventilators at the hospital,“ Alam said.




One health expert said using the decades-old doxycycline, which has been studied since the 1960s, is a plausible alternative to azithromycin.

“Since we’re talking about the elderly being the most vulnerable, or people with underlying conditions, there is a theoretical benefit of doxycycline over azithromycin because doxycycline is not associated with cardiovascular disease,” said Dr. Sten H. Vermund, the dean of the Yale School of Public Health.


Vermund also cautioned a clinical trial is necessary and also noted that two patients did pass away.

“I am optimistic about this combination, but a well-designed clinical study is urgently needed to identify the appropriate patient population, optimize dosing regimen and assess the side effect profile of this combination therapy,” added Dr. Ryan Saadi, a Yale-trained infectious disease epidemiologist who is currently developing a ventilator technology at Quantaira Health.



Vermund also added that other treatment alternatives that could be just as good and less toxic should also be considered.

And those treatment s are?




Dr. Muhammad Alum

Thank you for never giving up hope. A physician, that truly cared about the lives of his elderly patients, willing to try a controversial treatment in an attempt to save their lives.
The families of your patients must be thankful that they have a caring and determined doctor.
The following user(s) said Thank You: y4vix

Please Log in or Create an account to join the conversation.

More
3 months 2 days ago - 3 months 2 days ago #44398 by Isamorph
Replied by Isamorph on topic Covid-19 +
Some Covid/Corona Humor: Part I
The following user(s) said Thank You: PEW, als, Diedrich_Duo, Soteria 2.0, dst11, y4vix

Please Log in or Create an account to join the conversation.

More
3 months 2 days ago - 3 months 2 days ago #44399 by Isamorph
Replied by Isamorph on topic Covid-19 +
Attachments:
The following user(s) said Thank You: KentE, PEW, als, Diedrich_Duo, Soteria 2.0, dst11, y4vix

Please Log in or Create an account to join the conversation.