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9 months 5 hours ago #111 by 112059
Replied by 112059 on topic Pause for thought

Soteria 2.0 wrote: AMA Journal of Ethics

JAN 2012
Should Participation in Vaccine Clinical Trials be Mandated?
journalofethics.ama-assn.org/article/should-participation-vaccine-clinical-trials-be-mandated/2012-01


A quote from the link. "The modest financial remuneration commonly provided often means that students and the unemployed make up the bulk of volunteers [6, 8, 9]. As a result, the risks of developing a health intervention that would benefit the whole population are carried disproportionately by some of society’s most poor and vulnerable."


Maybe people willing to risk it all should share in a pool of stock options from the company that would gain from the testing and reap the rewards two or threefold what the CEO or CFO would get. Those that risk life or health should be rewarded more than those that risk time or money.
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8 months 3 weeks ago #112 by st3fx
Replied by st3fx on topic Pause for thought
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8 months 3 weeks ago #113 by Soteria 2.0
Replied by Soteria 2.0 on topic Pause for thought
AMA Journal of Ethics

JAN 2012
Should Participation in Vaccine Clinical Trials be Mandated?

The purpose of the post was to infer who may benefit from mandatory participation.

Bill Gates Foundation
Drug Companies
www.ncbi.nlm.nih.gov/pmc/articles/PMC3868822/

The European Commissioner for Research and Innovation signed an agreement with the Bill and Melinda Gates Foundation, with both parties pledging to fund research into drugs, vaccines and diagnostics to combat HIV, tuberculosis, malaria and other neglected infectious diseases.

It is anticipated that it will allow the development of at least one new and better health product per year. Mr Gates described the partnership as “critical to the success of our common mission…we can together improve the lives of millions.”

The Brazilian health minister announced a partnership between Bio–Manguinhos (Brazil’s leading medical research facility) and the Bill and Melinda Gates Foundation to develop and export an affordable combined measles and rubella vaccine.
The Gates Foundation has granted US$ 1.1 million to support clinical trials and the vaccine is expected to reach the market by 2017.

The Foundation announced a new initiative to develop vaccines to tackle child mortality in the developing world, where preventable diseases such as malaria and pneumonia are a leading cause of death. This scheme, known as the Vaccine Discovery Partnership, will see the Foundation working alongside pharmaceutical companies. Sanofi and GlaxoSmithKline (GSK) are the first to sign up, and it is hoped that others will soon follow.

By working with pharmaceutical companies the Foundation hopes to reduce the costs and risks associated with early–stage vaccine research, saying that “this will be a win for everyone involved.

Reduce costs.
Mandatory participation.
:sick:
The failure to support basic care as comprehensively as vaccines and research is a blind spot for the Gates Foundation, said Paul Farmer, recipient of a John D. and Catherine T. MacArthur Foundation fellowship, and founder of Partners in Health, which has received Gates Foundation funds for research and training.

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8 months 3 weeks ago #114 by Soteria 2.0
Replied by Soteria 2.0 on topic Pause for thought

112059 wrote:

Soteria 2.0 wrote: AMA Journal of Ethics

JAN 2012
Should Participation in Vaccine Clinical Trials be Mandated?
journalofethics.ama-assn.org/article/should-participation-vaccine-clinical-trials-be-mandated/2012-01


A quote from the link. "The modest financial remuneration commonly provided often means that students and the unemployed make up the bulk of volunteers [6, 8, 9]. As a result, the risks of developing a health intervention that would benefit the whole population are carried disproportionately by some of society’s most poor and vulnerable."


Maybe people willing to risk it all should share in a pool of stock options from the company that would gain from the testing and reap the rewards two or threefold what the CEO or CFO would get. Those that risk life or health should be rewarded more than those that risk time or money.


www.jci.org/articles/view/25694


The US Code of Federal Regulations requires that informed consent be obtained “under circumstances . . . that minimize the possibility of coercion or undue influence”
An inducement in clinical research, as defined in The official IRB guidebook , is deemed undue and therefore troublesome if it is so “. . . attractive that [it can] blind prospective subjects to potential risks or impair their ability to exercise proper judgment . . .”

Do financial incentives blind potential research participants to the risks of research when making decisions regarding participation? Motivated by cash payments

or an attractive financial package,
:)
an individual could have less interest in evaluating or understanding study details, reading the consent form, or attempting to understand the goals, purposes, and risks associated with a study.

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8 months 3 weeks ago #115 by Soteria 2.0
Replied by Soteria 2.0 on topic Pause for thought
In recent decades there has been a distressing decline in the numbers of healthy volunteers who participate in clinical trials [7], a decline that has the potential to become a key rate-limiting factor in vaccine development. Reasons for this decline are unclear but are likely to be multifaceted.

www.ncbi.nlm.nih.gov/pmc/articles/PMC2568492/
The Tuskegee Study of Untreated Syphilis and public perceptions of biomedical research: a focus group study.
Benjamin R. Bates and Tina M. Harris

African Americans are less likely than European Americans to participate in biomedical research. Researchers often attribute nonparticipation to the "Tuskegee effect."

It can't be dismissed as unwarranted.

From a historical perspective, the Tuskegee syphilis study is widely recognized as a reason for mistrust because of the extent and duration of deception and mistreatment and the study's impact on human subject review and approval.

www.law.cornell.edu/uscode/text/42/300aa-22
42 U.S. Code S 300aa–22.

Standards of responsibility
Vaccine manufacturers exempt from liability.
Unavoidable adverse side effects; warnings
(1) No vaccine manufacturer shall be liable in a civil action for damages arising from a vaccine-related injury or death associated with the administration of a vaccine after October 1, 1988

Controversial vaccine studies: Why is Bill & Melinda Gates Foundation under fire from critics in India?

m.economictimes.com/industry/healthcare/biotech/healthcare/controversial-vaccine-studies-why-is-bill-melinda-gates-foundation-under-fire-from-critics-in-india/articleshow/41280050.cms

The Bill & Melinda Gates Foundation insists it is committed to improving coverage and quality of immunization services but critics accuse it of funding organizations that are promoting the interests of vaccine makers.

India cuts some funding ties with Gates Foundation on immunization
www.google.com/amp/s/mobile.reuters.com/article/amp/idUSKBN15N13K

www.google.com/amp/s/amp.theguardian.com/global-development/2019/nov/28/polio-outbreaks-in-four-african-countries-caused-by-mutation-of-strain-in-vaccine

www.sciencemag.org/news/2019/04/dengue-vaccine-fiasco-leads-criminal-charges-researcher-philippines
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8 months 3 weeks ago #116 by Soteria 2.0
Replied by Soteria 2.0 on topic Pause for thought
Dark cloud over good works of Gates Foundation

www.google.com/amp/s/www.latimes.com/news/la-na-gatesx07jan07-story.html%3f_amp=true

In a contradiction between its grants and its endowment holdings, a Times investigation has found, the foundation reaps vast financial gains every year from investments that contravene its good works.

The Gates Foundation has poured $218 million into polio and measles immunization and research worldwide, including in the Niger Delta.

At the same time that the foundation is funding inoculations to protect health, The Times found, it has invested $423 million in Eni, Royal Dutch Shell, Exxon Mobil Corp., Chevron Corp. and Total of France — the companies responsible for most of the flares blanketing the delta with pollution, beyond anything permitted in the United States or Europe.

In addition, The Times found the Gates Foundation endowment had major holdings in:

• Companies ranked among the worst U.S. and Canadian polluters, including ConocoPhillips, Dow Chemical Co. and Tyco International Ltd.

• Many of the world’s other major polluters, including companies that own an oil refinery and one that owns a paper mill, which a study shows sicken children while the foundation tries to save their parents from AIDS.

• Pharmaceutical companies that price drugs beyond the reach of AIDS patients the foundation is trying to treat.

With the exception of tobacco companies, asset managers do not avoid investments in firms whose activities conflict with the foundation’s mission to do good.

LOL
It's good to know that they have a line.
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3 weeks 3 days ago #117 by TommyJ
Replied by TommyJ on topic Pause for thought
The experts came to the conclusion that we cannot avoid a global temperature rise of 1.5 degrees, we cannot avoid a global temperature rise of 1.5 degrees. Moreover, there is a huge possibility that humanity will fail in efforts to prevent 2 degrees of warming. People will have to adapt to life in a systemic world already in a decade. It cannot be called otherwise than an ecological catastrophe on a planetary scale.

The most vulnerable regions of the planet is the Arctic, but the ongoing changes show the climate of the entire Northern Hemisphere. Experts concluded that winter temperatures will inevitably rise by 3-5 degrees Celsius by 2050 and 5-9 degrees by 2080, as a result of which the polar regions will lose a lot of ice and sea level will rise across the globe. ... Let's say a miracle happens, and at one point all sources of greenhouse gases - cars, factories, and thermal power plants - stop emitting carbon dioxide. In this case, by 2100, winter temperatures will still rise by 4-5 degrees compared to the 20th century due to the delayed effect of carbon already emitted in the atmosphere.
Despite all the efforts of individual groups of scientists, an effective fight against this phenomenon is impossible.
We can only hope that they are wrong.

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3 weeks 3 days ago #118 by Chelle
Replied by Chelle on topic Pause for thought
President Obama and John Kerry both recently purchased multi million dollar waterfront homes.

As soon as they start worrying about it, I'll start worrying about it.

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3 weeks 3 days ago - 3 weeks 3 days ago #119 by KentE
Replied by KentE on topic Pause for thought
There probably isn't a group of more cold-hearted, non-partisan & non-political, neither establishment or anti-establishment, group than insurance company data analysts. You know, the ones who just doubled your daughter's car insurance rates because she's a red-head under 5'6" who drives a Lincoln Navigator on trips primarily under 3.1 miles, and recently moved 3 blocks away across the county line. The data tells them the increased risk is true, and they don't really worry about the 'why'.

The insurance industry believes climate change is real. They don't care why, except for how that knowledge predicts their risk, and helps minimize their exposure. .

from www.motherjones.com/politics/2005/04/profits-doom/
If you want to hear some tough talk about global warming, talk to an insurer. Take this recent statement by Richard Jones, the vice president for engineering of the Hartford Insurance Company. “Climate change is real,” said Jones. “To me, proving that earth’s climate is changing from human actions—namely global warming—is like statistically ‘proving’ the pavement exists after you have jumped out a 30-story building. After each floor, your analysis would say, ‘so far, so good,’ and then, at the pavement, all uncertainty is removed.”

EDIT: Changed  my statement  of "The insurance industry believes global warming is real"  to "The insurance industry believes climate change is real", which is more accurate according to the quoted article.

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